Grace L. Guo, MBBS, Ph.D.
EOHSI Room 322
Dr. Guo is an Associate Professor at the Department Pharmacology and Toxicology in the Ernest Mario School of Pharmacy of Rutgers University. She is an adjunct faculty of the Department of Pharmacology, Toxicology and Therapeutics in School of Medicine at the University of Kanas Medical Center. Dr. Guo obtained her MBBS degree from the West China University of Medical Sciences in 1993 and a PhD degree from the University of Kansas Medical Center in 2001, as well as post-doctoral training at the NCI, NIH in 2004. From 2004-2012, Dr. Guo has served as a faculty at the University of Kansas Medical Center.
Liver is essential for life and liver functions are tightly regulated. Particularly, the impact of intestine on liver homeostasis, function and diseases is significant, but this impact has been less studied. Our group has been focusing on determining the effects of intestine-liver crosstalks on liver metabolism and pathogenesis and the underlying molecular mechanisms, especially following disruption of endogenous homeostasis and exposure to xenobiotic chemicals.
2012 Presidential Poster Award, AASLD meeting (2)
2011 Presidential Poster Award, AASLD meeting
2010 Presidential Poster Award, AASLD meeting
2009 Presidential Poster Award, AASLD meeting
2009 Post award winner for Annual Liver Center Symposium, University of Kansas Medical Center
2007 First place in oral presentation in Annual Cancer Center Symposium, University of Kansas Medical Center
2005 BIRCWH/NIH scholar
Zhu Y, Dong Y, Zhou HH, Kong B, Aleksunes LM, Richardson JR, Li F, and Guo GL. Modulation of farnesoid X receptor results in post-translational modification of poly (ADP-ribose) polymerase 1 in the liver. Toxicol Appl Pharmacol. 2013, 266: 260-6.
Walesky C, Edwards G, Borude P, Li F, Kong B, Ma X, Guo GL, Apte U. Hepatocyte specific deletion of farnesoid X receptor delays, but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology 2012. 56:2344-52.
Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL. Mechanism of tissue-specific farnesoid x receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 2012.56:1034-43. Recommended by Faculty of 1000
Kong B, Csanaky IL, Aleksunes LM, Patni M, Chen Q, Ma X, Jaeschke H, Weir S, Broward M, Klaassen CD, Guo GL. Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity. Toxicol Appl Pharmacol. 2012.261(2):189-95.
A tea cathechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Li G, Lin W, Araya JJ, Chen TT, Timmermann BN, Guo GL. Toxicol Appl Pharmacol.2012. 258(1):268-74.
Pacyniak E, Hangenbuch B, Curtis K, Lehman-McKeeman L, and Guo GL, Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice. Toxicol Appl Pharmacol. 2011. 257(1):23-31.
Li G, Thomas AM, Hart SN, Zhong X, Wu D, Guo GL. Farnesoid X receptor activaton mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner. Mol Endo 2010. 24(7):1404-12.
Pacyniak E, Roth M, Hangenbuch B, and Guo GL. Mechanism of PBDE uptake into the liver: PBDE congeners are substrate of human hepatic OATP transporters. Tox Sci 2010, 115, 344-353.
Thomas A, Hart S, Kong B, Fang J, Zhong X, and Guo GL. Genome-wide tissue specific FXR binding in mouse liver and intestine. Hepatology 2010, 51:1410-9.
Maran RRM, Thomas A, Roth M, Sheng Z, Esterly N, Pinson D, Gao X, Zhang Y, Ganapathy V, Gonzalez FJ, Guo GL. FXR-deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development. J Pharmacol Exp Ther. 2009, 328:469-77. Highlighted by Editor
Kong B, Luyendyk JP, Tawfik O, Guo GL. FXR-deficiency induces non-alhocolic steatohepatitis in LDLr-knockout mie fed a high-fat diet. J Pharmacol Exp Ther. 2009, 328:116-22. Highlighted by Editor
Guo GL, Moffit JS, Nicol CJ, Aleksunes LM, Manautou JE and Gonzalez FJ: Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci. 82:374-80, 2004.
Guo GL, Lambert G, Negishi M, Ward J, Brewer HB Jr, Kliewer SA, Gonzalez FJ, Sinal CJ: Complementary roles of farnesoid x receptor, pregnane x receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem. 278:45062-45071, 2003.
Guo GL, Staudinger J, Ogura K and Klaassen CD: Induction of the rat organic anion transporting polypeptide 2 by pregnenolone-16a-carbonitrile is via interaction with the pregnane-x-receptor. Mol Pharmacol, 61:832-839, 2002.