Carol Gardner, Ph.D.
Ernest Mario School of Pharmacy
160 Frelinghuysen Road
Piscataway, NJ 08854
Mechanisms of hepatotoxicity caused by lipopolysaccharide or acetaminophen, including cellular and molecular effects on isolated hepatocytes, liver macrophages and endothelial cells; characterization of subpopulations of liver macrophages and endothelial following toxicant injury; modulating the immune response to hepatotoxicants to modify liver injury by using knockout mice; and mechanisms of tissue repair following toxicant-induced injury.
D.L. Laskin, V.R. Sunil, C.R. Gardner, and J.D. Laskin. 2011. Macrophages and tissue injury: Agents of defense or destruction? Annu. Rev. Pharmacol. Toxicol. 51:267-288. http://www.ncbi.nlm.nih.gov/pubmed/20887196
D.L. Laskin, C.R. Gardner, and J.D. Laskin. 2010. Phagocytes. Comprehensive Toxicology, Vol. 5, Immune System Toxicology, D. Lawrence, ed., Elsevier, Kidlington, pp. 133-153.
C.R. Gardner, J.P. Gray, L.B. Joseph, J. Cervelli, N. Bremer, Y. Kim, V. Mishin, J.D. Laskin, and D.L. Laskin. 2010. Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 245:36-46. http://www.ncbi.nlm.nih.gov/pubmed/20100502
C.R. Gardner and D.L. Laskin. 2008. Immunotoxicology. Toxicology and Risk Assessment: A Comprehensive Introduction, H. Greim and R. Snyder, eds., John Wiley & Sons, West Sussex, pp. 316-328.
C.R. Gardner and D.L. Laskin. 2007. Sinusoidal Cells in Liver Injury and Repair. Hepatotoxicity: From genomics to in-vitro and in-vivo models, S.C. Sahu, ed., The Wiley Co., London, pp. 341-370.
D.L. Laskin and C.R. Gardner. 2007. Role of sinusoidal cells and inflammatory macrophages in hepatotoxicity. Drug-Induced Liver Disease, 2nd ed., N. Kaplowitz and L. DeLeve, eds., Marcel Dekker, NY. pp. 159-185.
R.J. Laumbach, N. Fiedler, C.R. Gardner, D.L. Laskin, Z.H. Fan, J. Zhang, C.J. Weschler, P.J. Lioy, R.B. Devlin, P. Ohman-Strickland, K. Kelly-McNiel, and H.M. Kipen. 2005. Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. J. Occup. Environ. Med. 47(11):1182-1189. http://www.ncbi.nlm.nih.gov/pubmed/16282880