Directory

Carol Gardner, Ph.D.

Associate Director
Analytical Cytometry/Image Analysis Core Facility
Toxicology Division
Rutgers, The State University of New Jersey

Location:

Office: 012A

Ernest Mario School of Pharmacy

Rutgers University

160 Frelinghuysen Road

Piscataway, NJ 08854

Lab:

Room 001

Email: cgardner@pharmacy.rutgers.edu

Office: 848-445-6773
Lab: 732-445-4702

Research Areas

Mechanisms of hepatotoxicity caused by lipopolysaccharide or acetaminophen, including cellular and molecular effects on isolated hepatocytes, liver macrophages and endothelial cells; characterization of subpopulations of liver macrophages and endothelial following toxicant injury; modulating the immune response to hepatotoxicants to modify liver injury by using knockout mice; and mechanisms of tissue repair following toxicant-induced injury.

Research Highlights

Studies on polarization of liver macrophage and endothelial cell populations in rats and mice following acetaminophen intoxication.
Examination of drug interactions in mice treated with acetaminophen and an anthelminthic drug.
Effects of loss of caveolin on acetaminophen hepatotoxicity in mice.

Publications

D.L. Laskin, V.R. Sunil, C.R. Gardner, and J.D. Laskin. 2011. Macrophages and tissue injury: Agents of defense or destruction? Annu. Rev. Pharmacol. Toxicol. 51:267-288. http://www.ncbi.nlm.nih.gov/pubmed/20887196

D.L. Laskin, C.R. Gardner, and J.D. Laskin. 2010. Phagocytes. Comprehensive Toxicology, Vol. 5, Immune System Toxicology, D. Lawrence, ed., Elsevier, Kidlington, pp. 133-153.

C.R. Gardner, J.P. Gray, L.B. Joseph, J. Cervelli, N. Bremer, Y. Kim, V. Mishin, J.D. Laskin, and D.L. Laskin. 2010. Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 245:36-46. http://www.ncbi.nlm.nih.gov/pubmed/20100502

C.R. Gardner and D.L. Laskin. 2008. Immunotoxicology. Toxicology and Risk Assessment: A Comprehensive Introduction, H. Greim and R. Snyder, eds., John Wiley & Sons, West Sussex, pp. 316-328.

C.R. Gardner and D.L. Laskin. 2007. Sinusoidal Cells in Liver Injury and Repair. Hepatotoxicity: From genomics to in-vitro and in-vivo models, S.C. Sahu, ed., The Wiley Co., London, pp. 341-370.

D.L. Laskin and C.R. Gardner. 2007. Role of sinusoidal cells and inflammatory macrophages in hepatotoxicity. Drug-Induced Liver Disease, 2^nd ed., N. Kaplowitz and L. DeLeve, eds., Marcel Dekker, NY. pp. 159-185.

R.J. Laumbach, N. Fiedler, C.R. Gardner, D.L. Laskin, Z.H. Fan, J. Zhang, C.J. Weschler, P.J. Lioy, R.B. Devlin, P. Ohman-Strickland, K. Kelly-McNiel, and H.M. Kipen. 2005. Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. J. Occup. Environ. Med. 47(11):1182-1189. http://www.ncbi.nlm.nih.gov/pubmed/16282880