Directory

Mingzhu Fang, Ph.D.

Assistant Professor
Department of Environmental Occupational Medicine
Environmental and Occupational Health Sciences Institute
Robert Wood Johnson Medical School
UMDNJ

Location:

Room 412

Lab:

Room 409

Email: fang@eohsi.rutgers.edu

Office: 848 445 3720
Lab: 848-445-0216

Fax: 732 445 4161

Research Areas

Genetic and epigenetic mechanisms of carcinogenesis; Molecular targets for cancer prevention; Role of circadian rhythm on carcinogenesis and its application on chemoprevention and chemotherapy.

Scholarly Activities

2012 UMDNJ Foundation Seed Grant

2012 SOT Colgate-Palmolive Grant for Alternative Research

2010 NIEHS CEED Career Development Award

2009 NIEHS CEED Pilot Grant

2004 Annual Bibliography of Significant Advances in Dietary Supplements Research by ODS, NIH

2003 Honored on the Cover of Cancer Res

2003 Gallo Award in 2003 Annual Retreat on Cancer Research in New Jersey (ARCRNJ)

2002 The New Jersey Cancer Research Award for Scientific Excellence, 2002 ARCRNJ

2000 Yong Investigator Award, Asian Society of Toxicology, 2000 ASIATOX II

Selected Publications

Fang, M., Zhang, X., and Zarbl, H. (2010) Methylselenocysteine resets the rhythmic expression of circadian and growth regulatory genes disrupted by nitrosomethylurea in vivo. Cancer Prevention Research 3:640-52.

Yang, C.S., Fang, M., Lambert, J.D., Yan, P., and Huang, T.H. (2008) Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds. Nutrition Reviews 66: S18-S20.

Ren, X., Zhang, X., Kim, A.S., Mikheev, A.M., Fang, M., Sullivan, R., Bumgarner, R., Zarbl, H. (2008) Comparative genomics of susceptibility to mammary carcinogenesis among inbred rat strains: role of reduced prolactin signaling in resistance of the Copenhagen strain. Carcinogenesis, 29:177-85.

Fang, M., Chen D.P., and Yang, C.S. (2007) Dietary polyphenols may affect DNA methylation. J Nutrition, 131, 223S-228S.

Fang, M.Z., Chen, D., Sun, Y., Christman J.K., and Yang, C.S. (2005) Reversal of hypermethylation and reactivation of p16, RARβ, and MGMT genes by genistein and other isoflavones from soy. Clin. Cancer Res. 11: 7033-41.

Fang, M.Z., Jin, Z., Wang, Y., Liao, J., Yang, G-Y, Wang, L-D, Yang, C.S. (2005) Promoter hypermethylation and inactivation of O⁶-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines. Int. J. Oncol., 26:615-22.

Fang, M.Z., Liu, C., Song, Y., Yang, G-Y, Nie, Y., Liao, J., Zhao, X., Shimada, Y., Wang, L-D, and Yang, C.S. (2004) Overexpression of gastrin-releasing peptide (GRP) in human esophageal squamous cell carcinomas. Carcinogenesis, 25: 865-71.

Fang, M.Z.^*, Wang, Y.^*, Ai, N., Hou, Z., Sun, Y., Lu, H., Welsh, W., and Yang, C.S. (2003) The tea polyphenol epigallocatechin gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res., 63: 7563-70 * Fang, M.Z. and Wang, Y. contributed equally in this study.

Wang, Y.^*, Fang, M.Z.^*, Liao, J., Yang, G-Y, Nie, Y., Song, Y., So, C., Xu, X., Wang, L.D., Yang, C.S. (2003) Hypermethylation associated inactivation of retinoic acid receptor beta (RARβ) in human esophageal squamous cell carcinoma. Clin. Cancer Res., 9: 5257-63. *Wang, Y. and Fang, M.Z. contributed equally in this study.