Directory
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Panos G. Georgopoulos, Ph.D.
EOHSI Room 308 170 Frelinghuysen Road, Piscataway, NJ 08854
Fax: 732-445-0915 |
Mathematical Modeling of Environmental and Biological Systems and their Interactions - Computational Chemodynamics and Toxicodynamics:
Multimedia transport, fate and uptake of environmental pollutants; photochemical smog; air toxics; persistent organics; heavy metals • Physiologically-based toxicokinetics and pharmacokinetics; inhalation, ingestion and dermal absorption dosimetry • Mechanistic toxicodynamics and pharmacodynamics • Computational systems toxicology and toxicogenomics • Multiscale biological modeling (from molecule to cell to tissue to organism to population) for toxicity and environmental health assessment
Environmental and Human Exposure Information Systems Methods:
Multidimensional/spatiotemporal data mining and diagnostic analysis via Geographic Information and Database Management Systems • Multiroute/multipathway modeling of human exposure to toxics • Enviroinformatics, cheminformatics, and bioinformatics
Risk and Uncertainty Analysis Methods:
Uncertainty characterization, analysis and reduction methods for environmental and occupational health risk assessment
Examples of research projects that Dr. Georgopoulos has recently overseen and guided:
- Various applications of MENTOR (MOdeling ENvironment for TOtal Risk studies), a novel framework for source-to-dose exposure analyses for individuals and populations, with emphasis on situations involving cumulative and aggregate exposures to mixtures of chemicals in air, water, food, soil, dust, consumer products, etc.
- Development of the DORIAN (DOse Response Information ANalysis) system for multiscale mechanistic analysis of environment-biosystem interactions
- Development of a computer-based, planning support system for Areal Characterization of Hazard Impact and Location for Local Emergency Situations in New Jersey (ACHILLES-NJ) that provides screening “pre-assessments” of the impact (hazard and spatial extent) from potential atmospheric releases of hazardous materials from chemical facilities and transportation related incidents in New Jersey
- Applications of of ebTrack, an environmental bioinformatics system expanding the capabilities of USFDA’s ArrayTrack system
- Development of a prototype Exposure Information System (EXIS) for the National Children’s Study
- Development of computational modules for a multiscale modeling framework of hepatic transport, metabolism, elimination, and toxicodynamics of xenobiotics
- Development of novel multiscale mechanistic models of oxidative stress resulting from exposure to environmental contaminants with applications to arsenic and TCE
- Development of an Exposure Index (EI) for the National Children’s Study to support the analysis of pregnancy outcomes (pre-term births and low birth weights)
- Development of a regional atmospheric dynamic model of pollen production, distribution and dispersion and of population exposure and dose for various types of pollen co-occurring with various chemical air pollutants
- Testing of a prototype generalized risk analysis framework for engineered nanomaterials (ENMs) by implementing, adapting, and expanding the Modeling ENvironment for TOtal Risk studies (MENTOR) and the DOse Response Information and ANalysis system (DORIAN)
2010-2011 Member, Virtual Physiological Human (VPH) International Expert Group
2010-2011 Member, FIFRA Scientific Advisory Panel (FIFRA SAP) regarding scientific issues associated with Chlorpyrifos
2010 Member, USEPA Grant Review Panel, Computational Toxicology: Biologically-Based Multiscale Modeling
Efstathiou C., Isukapalli S.S. and Georgopoulos P.G. (2011). A mechanistic modeling system for estimating large scale emissions and transport of pollen and co-allergens. Atmospheric Environment 45 (13): 2260-2276. DOI:10.1016/j.atmosenv.2010.12.008.
Stamatelos S.K., Brinkerhoff C.J., Isukapalli S.S. and Georgopoulos P.G. (2011). Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes – Incorporation of cellular antioxidant response and threshold-dependent behavior. BMC Systems Biology 5 (16) DOI: 10.1186/1752-0509-5-16
Hogrefe C., Isukapalli S.S., Tang X., Georgopoulos P.G., He S., Zalewsky E.E., Hao W., Ku J.-Y., Key T. and Sistla G. (2011). Impact of biogenic emission uncertainties on the simulated response of O3 and PM2.5 to anthropogenic emission reductions. Journal of the Air and Waste Management Association 61: 92-108. DOI: 10.3155/1047-3289.61.1.92
Sasso A., Isukapalli S. and Georgopoulos P. (2010). A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals. Theoretical Biology and Medical Modelling 7 (1): 17. DOI: 10.1186/1742-4682-7-17
Yang Y., Xu X. and Georgopoulos P.G. (2010). A Bayesian population PBPK model for multiroute chloroform exposure. Journal of Exposure Science and Environmental Epidemiology 20 (4): 326-341. DOI: 10.1038/jes.2009.29. PMCID: 3063650.
Isukapalli S., Spendiff M., Georgopoulos P.G. and Krishnan K. (2010). Uncertainty, variability and sensitivity analyses in simulation models. In Quantitative Modeling in Toxicology. Krishnan, K. and Andersen, M. E. (eds.), John Wiley: pp.429-458. DOI: 10.1002/9780470686263.ch20
Georgopoulos P.G., Isukapalli S. and Krishnan K. (2010). Modeling exposures to chemicals from multiple sources and routes. In Quantitative Modeling in Toxicology. Krishnan, K. and Andersen, M. E. (eds.), John Wiley: pp.315-351 DOI: 10.1002/9780470686263.ch16
Xue J., Zartarian V., Wang S.W., Liu S.V. and Georgopoulos P.G. (2010). Probabilistic modeling of dietary arsenic exposure and dose and validation with 2003 NHANES data. Environmental Health Perspectives 118 (3): 345-350. DOI: 10.1289/ehp.0901205
Georgopoulos P.G. and Isukapalli S.S. (2009). A unified multiscale field/network/agent based modeling framework for human and ecological health risk analysis. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1: 6420-6423. DOI: 10.1109/IEMBS.2009.5333795
Georgopoulos P., Isukapalli S., Burke J., Napelenok S., Palma T., Langstaff J., Majeed M., He S., Byun D., Cohen M. and Vautard R. (2009). Air quality modeling needs for exposure assessment from the source-to-outcome perspective. Environmental Manager (October): 26-35.
Lioy P.J., Isukapalli S., Trasande L., Thorpe L., Dellarco M., Weisel C., Georgopoulos P.G., Yung C., Brown M. and Landrigan P. (2009). Using national and local extant data to characterize environmental exposures in the National Children’s Study (NCS): Queens County, New York. Environmental Health Perspectives 117(10): 1494-1504. DOI: 10.1289/ehp.0900623.
Laumbach R., Harris G., Kipen H., Georgopoulos P., Shade P., Isukapalli S., Efstathiou C., Galea S., Vlahov D. and Wartenberg D. (2009). Respiratory symptoms are not associated with estimated WTC plume intensity and respiratory symptoms among residents outside of lower Manhattan. American Journal of Epidemiology 170(5): 640-649. DOI: 10.1093/aje/kwp165
Wang S.-W., Tang X., Fan Z., Lioy P.J. and Georgopoulos P.G. (2009). Modeling personal exposures from ambient air toxics in Camden, New Jersey: An evaluation study. Journal of the Air and Waste Management Association 59: 733-746. DOI: 10.3155/1047-3289.59.6.733. PMCID: 3066844.
Chen M., Martin J., Fang H., Isukapalli S., Georgopoulos P.G., Welsh W.J. and Tong W. (2009). ebTrack: an environmental bioinformatics system built upon ArrayTrack. BMC Proceedings 3 (Suppl 2): S5. PMCID: 2654488.
Ierapetritou M.G., Georgopoulos P.G., Roth C.M. and Androulakis I.P. (2009). Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clinical and Translational Science 2 (3): 228-237. DOI: 10.1111/j.1752-8062.2009.00092.x
Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2009). Reconstructing population exposures to environmental chemicals from biomarkers: Challenges and opportunities. Journal of Exposure Science and Environmental Epidemiology 19 (2): 149-171. DOI: 10.1038/jes.2008.9
Gerecke D., Chen M., Isukapalli S., Gordon M.K., Chang Y.-C., Tong W., Androulakis I. and Georgopoulos P.G. (2009). Differential gene expression profiling of mouse skin after sulfur mustard exposure: extended time response and inhibitor effect. Toxicology and Applied Pharmacology 234 (2): 156-165. DOI: 10.1016/j.taap.2008.09.020. PMCID: 3066660.
Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Road, Piscataway, NJ 08854 - (848) 445-0200
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