Cancer chemoprevention and cancer therapy by differentiating agents

Our major areas of research are (a) studies on dietary inhibitors of carcinogenesis, (b) factors influencing the metabolism and action of estradiol, and (c) anticancer effects of the phorbol ester, TPA.

	Stimulatory effect of topical application of caffeine on UVB-induced apoptosis in the epidermis of p53 and Bax knockout mice. Lu YP, Lou YR, Peng QY, Xie JG, Conney AH. Cancer Res. 2004 Jul 15;64(14):5020-7.
	Dietary clofibrate inhibits induction of hepatic antioxidant enzymes by chronic estradiol in female ACI rats. Mesia-Vela S, Sanchez RI, Reuhl KR, Conney AH, Kauffman FC. Toxicology. 2004 Aug 5;200(2-3):103-11.
	Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. Nagai M, Conney AH, Zhu BT. Drug Metab Dispos. 2004 May;32(5):497-504.
	Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate alone or in combination with all-trans-retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice. Zheng X, Chang RL, Cui XX, Avila GE, Lee S, Lu YP, Lou YR, Shih WJ, Lin Y, Reuhl K, Newmark H, Rabson A, Conney AH. Cancer Res. 2004 Mar 1;64(5):1811-20.