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Mitochondrial dysfunction is an underlying mechanism associated with several neurodegenerative diseases, including Parkinson's disease. Our laboratory is studying the effects of energy impairment on dopamine neuronal degeneration. Using in vitro and in vivo approaches, studies
are directed at understanding cellular mechanisms of damage, the selective vulnerability of dopamine neurons and neuroprotective strategies. Also of interest are studies of environmental agents that target mitochondria and the dopamine system.
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Gluck, M., Ehrhart, J., Jayatilleke, E. and Zeevalk, G.D. (2002) Inhibition of brain mitochondrial
respiration by dopamine: involvement of H2O2 and hydroxyl radicals but not glutathione-protein mixed disulfides. J. Neurochem. 82:66-74 |
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Ehrhart, J., Gluck, M. and Zeevalk, G.D., (2002) Functional glutaredoxin (thioltransferase) activity in
brain and liver mitochondria.Parkinsonism and Related Disorders 8:395-400 |
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Ehrhart, J. and Zeevalk, G.D. (2003) Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures. J. Neurochem. 86: 1487-1497 |
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Associate Professor of Neurology
Division Lab Neuroscience, RWJMSP, RWJMS-Neurology, P CMHC-P 4 D401
Piscataway, NJ 08854
Phone: 732/235-3494
Fax: 732/235-5295 zeevalgd@umdnj.edu
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