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Research Focus – Redox Stress, Signaling and Carcinogenesis
Ah-Ng Tony Kong, Ph.D. has been studying cellular signaling, regulation of drug metabolizing enzymes and cellular protection genes by xenobiotics leading to protection against carcinogenesis for more than 15 years. Currently his laboratory is focusing on the signaling and activation of the antioxidant response element (ARE)-Nrf2, a bZIP transcription factor pathway, by oxidants, UVB and dietary phytochemicals (isothiocyanates and phenolic antioxidants EGCG/curcumin/ dibenzoylmethane); phosphorylation and control of nuclear trafficking of Nrf2; partnering of Nrf2 with nuclear co-regulators; disease models using Nrf2 knockout mice in colon, skin and lung cancer and cardiovascular and Parkinson Disease; suppression of NF-kB-inflammatory pathways by Nrf2 and dietary phytochemicals; pharmacokinetics and toxicogenomics of xenobiotics.
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