The research conducted in our laboratory focuses on biological and physical organic chemistry. In the biological chemistry area, the reactivity of nucleobases and nucleotides, including enzymes for which nucleic acids are substrates, is explored using methods such as mass spectrometry (MS) and computer modeling. Goals of this research include the improved understanding of DNA reactivity and enzyme catalysis toward the ultimate end of improved drug design. In the physical organic area, synthesis, MS, and theoretical methods are used to explore pericyclic rearrangements. Goals include identifying the root of acceleration in various reactions, toward the end of increasing the synthetic utility of these rearrangements.

If you need more information, more details can be found on my website:

http://rutchem.rutgers.edu/faculty/lee.html