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Research has focused largely
on toxicogenomics and functional genomics,
carcinogenesis, molecular and cellular
biology, and toxicology. Specifically this
has included work understand to molecular
mechanisms of chemical carcinogenesis and
the genetic basis for differential
susceptibility to mammary carcinogenesis
using both animal and in vitro model
systems. Studies in the rat model have
included analysis of oncogene activation,
mechanisms of signal transduction, and
genetic linkage analysis to identify mammary
tumor suppressor genes. He has also used
toxicogenomics to dissect mechanisms of
mechanism carcinogenesis, tumor progression
and chemopreven-tion. His studies in the
area of toxicogenomics include the
development and application of standards for
DNA microarray experiments, and phenotypic
anchoring of response of human cells, model
organisms (yeast) and target organs
(rodents) to toxicants, providing insights
into dose and temporal responses, as well as
mechanisms of action. He is also actively
involved in technology development,
including his patented work on RNAi and its
application to the development of novel
platforms (with Engineering Arts, Inc.) for
functional genomics and biomarker screening.
Helmut Zarbl, Professor in
Department of Environmental and Occupational
Medicine at the UMDNJ-RWJMS, and is a member
of the Toxicology Division at Environmental
and Occupational Health Sciences Institute.
He also serves as the Director of the NIEHS
sponsored Center for Environmental Exposures
and Disease. He serves on numerous national
research review and advisory panels, and is
the Editor in Chief of the journal,
'Biological Procedures Online'. Dr. Zarbl is
renowned for his work in areas of
toxicogenomics, and mechanisms of and
genetic susceptibility to chemical
carcinogenesis, mechanisms of mutagenesis
and toxicity, and technology development.
These research efforts have to date resulted
in over 70 scientific papers and book
chapters. |
