| |
|
The Biostatistics, Bioinformatics, and Computational Toxicology Facility Core (BBCT)
Core Director: Panos. Georgopoulos, PhD
Core Director: Weiching (Joe) Shih
The BBCT is pivotal to integration of data from of all Facility and Disease Cores. It serves as the gateway
for biostatistical and informatics-based queries and a clearinghouse for data formatting, transfer, and
analysis, as well as modeling exposures and outcomes.
| The three components of this important Core
include: |
- Biostatistics
provides consultation during the preparation of Center proposals and subsequent data analysis. Center Pilot Grant applications go through an initial review of experimental design and statistical power .This ensures the integration of appropriate biostatistics into experimental design before selection of appropriate technologies and analytical tools.
- Bioinfomatics
provides the tools, staff and training to assist Center investigators in the analysis and integration of the different data types. For example, gene expression profiling data are integrated with data from exposure assessment, SNP data, and phenotypic analyses to define pathogenic mechanisms. For investigators more experienced in bioinformatics methods or those performing studies that require higher levels of data analysis, modeling support, or integration, the Core can provide expert consultation for the use or development of appropriate customized tools for information analysis.
- Modeling and Computational Toxicology
provides leadership in the development of computational approaches to model exposure on the basis of ambient levels of toxicants, routes of exposure, behavior, lifestyle, pharmacokinetic parameters, genotype, and mechanisms of pathogenesis. This exposure to phenotype modeling provides information for population based studies where individual exposure levels are not available and generates testable hypotheses on dose-response relationships.
|
|
